Jewish Housewives' Disease's less fun name is Diphyllobothriasis, and it's caused by a tapeworm that's found in some types of fish. If you cook the fish that contains this tapeworm (full name: Diphyllobothrium latum), then no biggy. But if you eat it raw or undercooked, then you can get an infection that's sometimes hard to diagnose because you get very non-specific symptoms - stomach pain, anemia, fatigue [read about a real-life tale of a tapeworm from the NY Times].
So why are Jewish housewives most infected? Because the world hates Jews? Maybe. But more likely it's because Jewish housewives make homemade gefilte fish (or at least they used to) - which is basically a delicious mushed-up ball of all different kinds of fish as well as an excellent excuse to eat gobs of horseradish. And like any good cook (not that I would know), they would taste the gefilte fish to make sure it was perfectly flavored before they cooked it - aka raw. And then... they would get INFECTED. And to get better, they would have to take MEDICINE.
It's the making for the perfect horror movie, right? I already thought of the tag line (read slowly in a deep, menacing voice). "All she wanted for Passover was to impress her mother-in-law with homemade gefilte fish. She didn't ask for the uninvited guest ... in her BELLY."
Stephen King and I are already collaborating on the script, if anyone else wants in.